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Jonathan A Prince Selected Research

Insulysin (Insulin-Degrading Enzyme)

9/2007Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.
7/2005Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease.
6/2005Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.
8/2004Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels.
6/2004Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease.
11/2003Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.

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Jonathan A Prince Research Topics

Disease

24Alzheimer Disease (Alzheimer's Disease)
06/2013 - 04/2003
7Dementia (Dementias)
01/2011 - 09/2009
4Amyloid Plaque
09/2007 - 11/2003
3Myocardial Infarction
01/2013 - 12/2003
2Atherosclerosis
01/2013 - 01/2010
2Type 2 Diabetes Mellitus (MODY)
08/2009 - 08/2004
2Insulin Resistance
08/2004 - 12/2003
1Lipid Metabolism Disorders (Metabolism Disorders, Lipid)
01/2013
1Atrophy
01/2011
1Neurodegenerative Diseases (Neurodegenerative Disease)
09/2009
1Crohn Disease (Crohn's Disease)
08/2009
1Disease Progression
01/2009
1Frailty
08/2008
1Hypoxia (Hypoxemia)
05/2007
1Coronary Disease (Coronary Heart Disease)
05/2007
1Parkinson Disease (Parkinson's Disease)
01/2007
1Neuroinflammatory Diseases
11/2006
1Cataract (Cataracts)
11/2005
1Hyperhomocysteinemia
11/2005
1Alcoholism (Alcohol Abuse)
05/2005
1Obesity
11/2004
1Metabolic Syndrome (Dysmetabolic Syndrome X)
12/2003

Drug/Important Bio-Agent (IBA)

10Apolipoproteins E (ApoE)IBA
01/2011 - 04/2003
6Proteins (Proteins, Gene)FDA Link
01/2012 - 11/2003
6Amyloid beta-PeptidesIBA
02/2010 - 11/2003
6Insulysin (Insulin-Degrading Enzyme)IBA
09/2007 - 11/2003
5LipidsIBA
01/2013 - 08/2009
5Amyloid (Amyloid Fibrils)IBA
01/2012 - 11/2003
4Biological ProductsIBA
10/2010 - 11/2003
3sortilinIBA
06/2013 - 02/2010
3Peptides (Polypeptides)IBA
01/2011 - 08/2004
3Peptide Hydrolases (Proteases)FDA Link
10/2010 - 06/2006
3ApolipoproteinsIBA
03/2006 - 08/2005
2Neprilysin (Neutral Endopeptidase)IBA
01/2012 - 10/2010
2MMEIBA
01/2012 - 10/2010
2Interleukin-6 (Interleukin 6)IBA
01/2011 - 12/2003
2C-Reactive ProteinIBA
01/2011 - 12/2003
2Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
01/2009 - 08/2005
2CytokinesIBA
11/2006 - 12/2003
2Insulin (Novolin)FDA Link
11/2004 - 08/2004
1Metalloendopeptidases (Metalloendopeptidase)IBA
01/2012
1EnzymesIBA
01/2012
1CholesterolIBA
03/2010
1Apolipoproteins B (ApoB)IBA
03/2010
1Genetic Markers (Genetic Marker)IBA
02/2010
1oxidized low density lipoproteinIBA
01/2010
1Phosphopyruvate Hydratase (Enolase)IBA
01/2009
1Plasminogen Activator Inhibitor 1IBA
06/2007
1Prothrombin (Factor II)IBA
05/2007
1Nuclear Proteins (Protein, Nuclear)IBA
05/2007
1Interleukin-10 (Interleukin 10)IBA
11/2006
1Cathepsin DIBA
06/2006
1Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA
11/2005
1Folic Acid (Vitamin M)FDA LinkGeneric
11/2005
1DNA (Deoxyribonucleic Acid)IBA
11/2005
1Neuropeptide YIBA
05/2005
1preproneuropeptide YIBA
05/2005
1Glucose (Dextrose)FDA LinkGeneric
11/2004
1Amino AcidsFDA Link
05/2004
1Cholesterol 24-Hydroxylase (CYP46A1)IBA
05/2004
1Cytochrome P450 Family 46 (CYP46)IBA
05/2004
1tau Proteins (tau Protein)IBA
05/2004
1CateninsIBA
04/2004
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
11/2003